Differentially Expressed Heterogeneous Overdispersion Gene Test for Count Data

Implements a generalized linear model approach for detecting differentially expressed genes across treatment groups in count data. The package supports both quasi-Poisson and negative binomial models to handle over-dispersion, ensuring robust identification of differential expression. It allows for the inclusion of treatment effects and gene-wise covariates, as well as normalization factors for accurate scaling across samples. Additionally, it incorporates statistical significance testing with options for p-value adjustment and log2 fold range thresholds, making it suitable for RNA-seq analysis as described in by Xu et al., (2024) .


Reference manual

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install.packages("DEHOGT")

0.99.0 by Arlina Shen, 2 years ago


https://github.com/ahshen26/DEHOGT


Report a bug at https://github.com/ahshen26/DEHOGT/issues


Browse source code at https://github.com/cran/DEHOGT


Authors: Qi Xu [aut] , Arlina Shen [cre] , Yubai Yuan [ctb] , Annie Qu [ctb]


Documentation:   PDF Manual  


GPL-3 license


Imports doParallel, foreach, MASS

Suggests knitr, rmarkdown, BiocStyle


See at CRAN