Genotype-by-Environment Interaction in Polygenic Score Models

A novel PRS model is introduced to enhance the prediction accuracy by utilising GxE effects. This package performs Genome Wide Association Studies (GWAS) and Genome Wide Environment Interaction Studies (GWEIS) using a discovery dataset. The package has the ability to obtain polygenic risk scores (PRSs) for a target sample. Finally it predicts the risk values of each individual in the target sample. Users have the choice of using existing models (Li et al., 2015) , (Pandis et al., 2013) , (Peyrot et al., 2018) and (Song et al., 2022) , as well as newly proposed models for genomic risk prediction (refer to the URL for more details).