Confidence Intervals and Tests for Comparisons of Binomial
Proportions or Poisson Rates
Computes confidence intervals for binomial or Poisson rates
and their differences or ratios. Including the rate (or risk)
difference ('RD') or rate ratio (or relative risk, 'RR') for binomial
proportions or Poisson rates, and odds ratio ('OR', binomial only).
Also confidence intervals for RD, RR or OR for paired binomial data,
and estimation of a proportion from clustered binomial data. Includes
skewness-corrected asymptotic score ('SCAS') methods, which have been
developed in Laud (2017) from Miettinen and
Nurminen (1985) and Gart and Nam (1988)
, and in Laud (2026, under review) for paired
proportions. In each case, the same score produces hypothesis tests that are
improved versions of the non-inferiority test for binomial RD and RR
by Farrington and Manning (1990) , or a
generalisation of the McNemar test for paired data. The package also
includes MOVER methods (Method Of Variance Estimates Recovery) for all
contrasts, derived from the Newcombe method but with options to use
equal-tailed intervals in place of the Wilson score method, and
generalised for Bayesian applications incorporating prior information.
So-called 'exact' methods for strictly conservative coverage are
approximated using continuity adjustments, and the amount of
adjustment can be selected to avoid over-conservative coverage. Also
includes methods for stratified calculations (e.g. meta-analysis),
either with fixed effect assumption (matching the CMH test) or
incorporating stratum heterogeneity.