Spectral Clustering-Based Method for Identifying B Cell Clones

Provides a computational framework for identification of B cell clones from Adaptive Immune Receptor Repertoire sequencing (AIRR-Seq) data. Three main functions are included (identicalClones, hierarchicalClones, and spectralClones) that perform clustering among sequences of BCRs/IGs (B cell receptors/immunoglobulins) which share the same V gene, J gene and junction length. Nouri N and Kleinstein SH (2018) . Nouri N and Kleinstein SH (2019) . Gupta NT, et al. (2017) .

SCOPer

SCOPer (Spectral Clustering for clOne Partitioning) provides a computational framework for the identification of B cell clonal relationships from Adaptive Immune Receptor Repertoire sequencing (AIRR-Seq) data. It includes methods for assigning clonal identifiers using sequence identity, hierarchical clustering, and spectral clustering. SCOPer is part of the Immcantation analysis framework.

Contact

If you need help or have any questions, please contact the Immcantation Group.

If you have discovered a bug or have a feature request, you can open an issue using the issue tracker.

To receive alerts about Immcantation releases, news, events, and tutorials, join the Immcantation News Google Group. Membership settings can be adjusted to change the frequency of email updates.