Interim Monitoring of Clinical Trials with Time-Lagged Outcome

Implements inverse and augmented inverse probability weighted estimators for common treatment effect parameters at an interim analysis with time-lagged outcome that may not be available for all enrolled subjects. Produces estimators, standard errors, and information that can be used to compute stopping boundaries using software that assumes that the estimators/test statistics have independent increments. Tsiatis, A. A. and Davidian, M., (2022) .


Reference manual

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install.packages("tLagInterim")

1.1 by Shannon T. Holloway, a year ago


Browse source code at https://github.com/cran/tLagInterim


Authors: Shannon T. Holloway [aut, cre] , Marie Davidian [aut] , Anastasios Tsiatis [aut]


Documentation:   PDF Manual  


GPL-2 license


Imports R.utils

Depends on survival


See at CRAN