A step-up test for genetic rare variants in a gene or in a pathway. The method determines an optimal grouping of rare variants analytically. The method has been described in Hoffmann TJ, Marini NJ, and Witte JS (2010) .
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0.4-2 by Thomas Hoffmann, 8 years ago
http://sites.google.com/site/thomashoffmannproject/ https://doi.org/10.1371/journal.pone.0013584
Browse source code at https://github.com/cran/thgenetics
Authors: Thomas Hoffmann <tjhoffm@gmail.com>
Documentation: PDF Manual
GPL license
See at CRAN